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Clinical characteristics, trichoscopy, histopathology and treatment outcomes of frontal fibrosing alopecia in an Asian population: A retro‐prospective cohort study

The Journal of Dermatology Jul 29, 2020

Panchaprateep R, Ruxrungtham P, Chancheewa B, et al. - In this retro‐prospective cohort study involving patients diagnosed with frontal fibrosing alopecia (FFA) from January 1, 2010, to November 1, 2019, researchers sought to describe the clinical, trichoscopic and histopathological findings as well as treatment outcomes. All individuals were requested to present for re‐examination. Clinical, trichoscopic, histopathological, and laboratory data have been recorded. All 58 patients with FFA were females, of which 27.6% were premenopausal, 37.7% had a history of surgical menopause, 13.8% had thyroid diseases, 69% had eyebrow loss and 32.8% facial papules. Lack of follicular ostia, perifollicular scales and perifollicular erythema were the most common trichoscopic characteristics in the frontal hairline. It was noted that diffuse and pseudo‐fringe sign patterns are common in Asian FFA. Thyroid disease is the most common autoimmune systemic comorbidity, while female pattern hair loss, lichen planopilaris, and lichen planus pigmentosus are common concomitant dermatological diseases. The most effective therapy is antiandrogens or antimalarial plus topical treatment.

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