Egeberg A, et al. - In adult patients with psoriasis and atopic dermatitis (AD), researchers characterized and compared disease features, life-style factors and disease burden. Registry data were linked with clinical and patient reported outcomes from the Danish Skin Cohort, ie, 3,348 and 3,834 adults with dermatologist-verified psoriasis or AD respectively, and 2,946 general population adults. Participants in the study were predominantly women and middle-aged. Investigators found that patients with psoriasis reported disease onset mostly during adulthood, but with a distinct early incidence-peak in those with a positive family history or severe disease. They observed that atopic dermatitis predominantly started in childhood with only a very discrete incidence peak in adulthood. Involvement of the scalp, extremity, chest and abdomen was common to both diseases. Scalp/hairline, elbows, nails, intergluteal cleft, umbilicus, knees and legs have been most commonly affected in patients with psoriasis. Periocular, neck, ante-cubital fossae, back of the hands, interdigital areas, and popliteal fossae were commonly affected in AD. Patients with psoriasis but not AD were generally more overweight and obese, physically inactive, and had a positive smoking history vs the general population. With increasing disease severity, both diseases experienced more frequent flares. Despite being on systemic therapies, patients generally exhibited uncontrolled disease. Itch, skin pain, and disturbed sleep in patients with AD were much more severe, while joint pain in patients with psoriasis was more common. These similarities and differences should help physicians to prioritize and improve patient management.