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Clinical characteristics, respiratory mechanics, and outcomes in critically ill individuals with COVID-19 infection in an underserved urban population

Respiratory Care May 31, 2021

Chaudhary S, Benzaquen S, Woo JG, et al. - In the United States, COVID-19 outbreak has disproportionately affected Black individuals, however, there is little understanding of the factors that underlie this finding, researchers examined these links with mortality in a largely minority underserved population by conducting this single-center retrospective observational analysis including 128 critically ill adult patients with laboratory-confirmed SARS-Cov-2 treated in ICU between March 15 and May 10, 2020. Lower in-patient death in relation to asthma was observed, mainly in Black individuals. Factors that were independently related to in-patient death among Black individuals included increased age, positive fluid balance, and treatment with tocilizumab, while protective impact was exerted by factors such as higher platelets and treatment with intermediate dose anticoagulants. Findings showed that mortality rates attributable to COVID-19 were similar among Black and other race/ethnicity individuals but factors that were related to elevated risk of death varied between people of Black or other race/ethnicity. In both populations, older age, a positive fluid balance, less improvement in P aO2 /F IO2 , PEEP, and F IO2 need on ventilation were present in people who died.

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