Hsia Y, et al. - Eyes with unilateral disc hemorrhage (DH) in different locations were compared regarding the clinical characteristics and outcomes. In this retrospective cohort study, researchers classified DHs with respect to locations: the superior, superotemporal, inferotemporal, or inferior sectors of optic disc were classified as the susceptible area, while other sectors were defined as the less susceptible area. Less myopia and more peripapillary-type DH, larger cup-to-disc ratio, cup volume, and disc area were evident in 43 eyes with DHs in the susceptible area. They noted less association with RNFL defects, greater tilted ratio, and less torsion of the disc in 33 eyes with DHs in the less susceptible area. Follow-up revealed that DHs in the susceptible area had significantly greater change in sectoral RNFL (μm) thickness within one year (− 6.0 ± 14.0 vs 0.7 ± 13.0) and two years (− 10.0 ± 17.4 vs − 1.1 ± 7.6), while no difference in the change in average RNFL thickness was evident. Outcomes here suggest more subsequent structural and functional deterioration in correlation with disc hemorrhage in the superotemporal and inferotemporal regions vs eyes with DHs in the temporal quadrant and nasal area.