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Clinical characteristics of 1,055 Chinese patients with Mayer-Rokitansky-Küster-Hauser syndrome: A nationwide multicentric study

Fertility and Sterility Mar 26, 2021

Chen N, Pan H, Luo G, et al. - Researchers conducted a retrospective study with the aim to determine the proportion of concomitant extragenital malformations in a large cohort of Chinese patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Among a total of 1,055 Chinese Han women with MRKH syndrome diagnosed and treated at 11 Chinese tertiary teaching hospitals, 69.6% had type I MRKH syndrome and the remaining 30.4% had type II MRKH syndrome. Findings revealed relatively less common occurrence of type II disease among Chinese patients with MRKH syndrome vs European patients. In this cohort, more commonly observed extragenital malformations were skeletal malformations vs renal malformations. The 2 main skeletal malformations were idiopathic scoliosis and congenital vertebral malformations and the most common renal malformations were unilateral renal agenesis and ectopic kidney.

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