Schneer S, Khoury J, Adir Y, et al. - Whether the presence of Escherichia coli (E. coli) in respiratory secretions holds any clinical and prognostic value, was investigated in this study. Researchers screened cultures of respiratory secretions from hospitalized and outpatients for isolation of E. coli. Three categories of patients were defined: “Sensitive (S)”- growth of E. coli sensitive to all antimicrobials examined; Intermediate (I) - resistant to 1-2 antimicrobial classes; and “Resistant (R)”- resistant to at least three antibiotic classes. The factors related to resistant strains and outcomes were compared between the groups. They found 80 patients with E. coli isolates from respiratory secretions while screening 177,712 (4.5: 10,000 samples). Findings revealed the uncommon occurrence of pulmonary infection because of E. coli. Isolation of resistant E. coli was related to the length of prior hospitalization, raised mortality and may be seen as a nosocomial pathogen.