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Clinical characteristics and outcomes in elderly women with BRCA1 and BRCA2 mutations

Gynecologic Oncology Jun 06, 2019

Salyer C, et al. - In this retrospective analysis, researchers assessed clinical features and risk-reducing strategies used by women with a BRCA mutation who succeeded in living to age 75 and above. They identified participants from a California health care system. At study entry and at time of genetic testing, the median age of the cohort was 78 (IQR: 76–84) and 73 (IQR 68–79), respectively. Receipt of genetic test result at an older age and having a history of BRCA-related cancer was found in the majority of women with BRCA mutations living past age 75. Continuation of surveillance and risk reducing surgeries at an older age by women was also evident. In older BRCA mutation carriers, the most common new cancer diagnosed was pancreatic cancer.

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