Salyer C, et al. - Via a retrospective study of women with BRCA mutations identified from 1995 to 2015 in a California health care system of 69 women who lived to age 75 or older, the researchers reported clinical features and risk-reducing approaches used among women with a BRCA mutation who lived to age 75 and above. Out of 69, 50 women had a previous history of breast cancer and 27 had a history of ovarian cancer. Following the positive genetic test, 3 of 19 women with no history of breast cancer were selected to undergo a risk-reducing mastectomy. Fourteen underwent a risk-reducing salpingo-oophorectomy, out of which six were age 70 or older at the time of surgery, amongst 30 women with ovaries still in place. Four women in the cohort developed BRCA-related cancer following testing, one developed breast cancer, and three developed pancreatic cancer. Hence, most women with BRCA mutations who were living beyond age 75 got their genetic test result at an older age with a history of BRCA-related cancer. At an older age, women continued surveillance and risk-reducing surgeries. In older BRCA mutation carriers, pancreatic cancer was the most prevalent new cancer diagnosed.