Liu YL, Xiao WM, Liang MQ, et al. - Since Wernicke encephalopathy (WE) is a rare but severe neurological disorder caused by thiamine (vitamin B1) deficiency, researchers conducted this retrospective study to examine the clinical features and neuroimaging findings of nine patients (mean age was 54.0 ± 17.1 years) with nonalcoholic WE. They gathered a range of demographic and clinical variables for each patient, including age, gender, risk factors (eg, acute pancreatitis, cancer and hyperemesis gravidarum), clinical manifestations (including ocular signs, cerebellar signs, altered mental status or mild memory impairment) and initial hematological findings. Investigators found that fasting in nonalcoholic patients is a common cause of WE and that MRI is a useful tool for diagnosing WE. Symmetrical lesions of medial thalamus lesions were the most common MRI findings, followed by midbrain tectal plate and cranial nerve nuclei. In addition, MRI showed other WE-related lesions in mammillary bodies, the periaqueductal region, the tectal plate of the midbrain, cranial nerve nuclei and in the symmetric subcortical white matter.