Katz AD, et al. - In this retrospective review of prospective data, experts defined the clinical, radiographic, and complication-related outcomes through ≥ 1-year of 27 individuals who had undergone lateral lumbar interbody fusion (LLIF) with posterior instrumentation to treat ≥ 3 contiguous levels of degenerative lumbar scoliosis. In 74% of cases, EBL was ≤ 100 mL. Clinical outcomes continued to be considerably enhanced at ≥ 1-year. Cobb angle was fixed from 21.1 to 7.9 degrees, lordosis from 47.3 to 52.6 degrees, and mismatch from 11.4 to 6.4 degrees. In three individuals occurrence of high-grade subsidence was noted. Subsidence did not notably influence primary outcomes. Additionally, for complication-related intervention over nearly 2-years, 11.1% came back to the operating room and 37% encountered complications. Encountering a complication was related to having an open-posterior portion, although not with number of LLIF levels treated, or with clinical or radiographic outcomes. No individuals encountered protracted neurological deficiency and psoas weakness was correlated with elevated lateral operative time and reduced surgeon experience. In conclusion, individuals who underwent multilevel LLIF with adjunctive posterior surgery had important clinical and radiographic betterments. Moreover, in contrast to literature on single-level LLIF, complication rates were comparable. Thus, for multilevel degenerative scoliosis, LLIF is a feasible treatment.