Wong MW, et al. - In this analysis, researchers assessed clinical and psychological differences between gastroesophageal reflux disease (GERD) patients with vs without symptoms of laryngopharyngeal reflux (LPR), defined as reflux of gastric content reaching above the upper esophageal sphincter. Participants in the study were 303 consecutive patients who were proton pump inhibitor-naïve scheduled for upper endoscopy due to reflux symptoms recognized as GERD by non-dyspepsia reflux disease questionnaire score. There were 132 (43.6%) GERD patients with LPR symptoms and 171 (56.4%) GERD patients without LPR symptoms. More depression, sleep disturbance, irritable bowel syndrome, functional dyspepsia, and reflux symptoms burden were seen in GERD patients with symptoms of LPR vs those without symptoms of LPR. Overall, the authors suggested that more reflux symptoms, psychological distress, and functional gastrointestinal disturbance, but less erosive esophagitis was seen in gastroesophageal reflux disease patients with LPR symptoms.