Josifovska N, et al. - Researchers sought for a reliable clinical marker which can be a putative marker for retinal detachment (RD) as well as prognostic factor for surgical success or outcome, following identification of molecular markers such as presence of inflammatory cytokines in the subretinal fluid (SRF), and the effect of SRF upon dead cell clearance in the retina. Optical coherence tomography (OCT) was performed on 12 patients with rhegmatogenous RD (rRD) before and after 23G vitrectomy for RD. They collected pure SRF during surgery and analyzed it by protein array profiling on a panel of 105 inflammatory cytokines (Human XL Cytokine Array). Quantification of the effect of SRF upon human macrophages-driven phagocytosis of apoptotic retinal pigment epithelial (RPE) cells ex vivo was done by flow cytometry. As per findings, presence of hyper reflective points (HRPs) at the detached neuroretina border on OCT are the hallmark of fresh RD; successful reattachment surgery leads to a reduction of the size and number of the HRPs, and these likely resemble the macrophage conglomerates seen by immunohistochemistry. Thy noted progenitor/stem-like cells and signs of inflammatory reaction in the neuroretina in RD, while the SRF displayed inflammatory cytokines and other factors which enhance the ability of professional phagocytes to engulf dying RPE, or for that matter, other dying cells in the retina.