ILAG JS, et al. - This research was sought to distinguish age-specific clinical and/or serological patterns in juvenile-onset systemic lupus erythematous (JSLE) patients enrolled to the UK JSLE Cohort Study. Researchers analyzed and grouped patient records based on age at disease-onset: pre-pubertal (≤7 years), peri-pubertal (8–13 years) and adolescent (14–18 years). This study evaluated presence of American College of Rheumatology classification criteria, laboratory results, disease activity [British Isles Lupus Assessment Group and Systemic Lupus Erythematosus Disease Activity Index 2000 scores] and damage [Systemic Lupus International Collaborating Clinics damage index] at diagnosis and last follow up. There were a sum of 418 JSLE patients who were included in this study. The results of this study show that disease presentations and laboratory findings vary significantly between age groups within a national cohort of JSLE patients. Compared with younger patients, patients diagnosed during adolescence reveal greater disease activity and “classic” autoantibody, immune cell and complement patterns. The findings considered that pathomechanisms may vary between patient age groups.