Bhatia HS, Nishimura M, Dickson S, et al. - This study intended to longitudinally define methamphetamine-associated heart failure patients with reduced (METHrEF) and preserved (METHpEF) left ventricular ejection fraction (EF), and assess the correlation between methamphetamine cessation and clinical outcomes. Researchers conducted a retrospective cohort study and examined medical records of individuals with METHrEF, METHpEF, and controls with heart failure but without methamphetamine use. For up to 12 months, they recorded echocardiographic variables, with clinical follow-up extending to 24 months. This study's findings demonstrate that significant improvement in left ventricular systolic function and fewer heart failure admissions are seen in METHrEF individuals who stop using methamphetamines, which shows that METHrEF may be reversible. Some individuals with METHpEF may have pulmonary hypertension in the absence of overt signs of left ventricular diastolic dysfunction, as seen via echocardiographic parameters, but further study is required.