Chunawala ZS, Fudim M, Arora S, et al. - A high comorbidity burden as well as risk of death was recorded among patients with heart failure with preserved ejection fraction (HFpEF); this was noted irrespective of the cause of hospitalization.

• An ejection fraction ≥ 50% defined HFpEF.

• Researchers sampled a total of 13,706 weighted (2,936 unweighted) hospitalizations (mean age 77 years, 64% women, 29% Black) among patients with HFpEF and adjudicated acute decompensated heart failure (ADHF) (86%) or chronic stable heart failure (CSHF) (14%).

• Both, ADHF and CSHF hospitalizations, linked with a high comorbidity prevalence, irrespective of gender.

• A greater prevalence of hypertension (89% vs 84%) diabetes mellitus (48% vs 39%) and renal disease (85% vs 74%) was observed among women hospitalized with ADHF vs CSHF.

• Relative to CSHF, ADHF is more commonly linked with echocardiographic features such as left ventricular hypertrophy and valvular abnormalities, for both genders.

• However, ADHF and CSHF linked with comparable 28-day and 1-year mortality risk.