Abbara A, et al. - In this retrospective review, researchers analyzed the clinical features, predisposing factors, biochemistry and clinical outcome of patients presenting with pituitary apoplexy to Imperial College Healthcare NHS Trust between 1991 to 2015. Sixty-four patients with pituitary apoplexy (more complete clinical records were available in 52 patients) were identified. Findings revealed that pituitary apoplexy was the first presentation of pituitary disease in 38/52 of patients and predisposing factors were identified in 28/52. In patients with non-functioning pituitary adenomas (47/52), pituitary apoplexy predominantly occurred. It was noted that symptoms of meningeal irritation were reported in 7/18 and visual abnormalities in 22/35. The study findings suggested that these data characterized the clinical features of pituitary apoplexy to help the clinician in diagnosing this rare emergency presentation of pituitary disease.