Clearance of magnesium in peritoneal dialysis patients: A single-center study
Blood Purification Feb 02, 2019
Li G, et al. - Researchers focused on the clearance of magnesium (Mg) as well as on factors influencing it in 115 patients on peritoneal dialysis (PD) included in this retrospective analysis. They examined the demographic information, clinical characteristics and laboratory data of the patients. Three groups of patients were defined taking into account the corrected serum Mg (cS-Mg) concentration: hypomagnesemia (Mg2+ < 0.77 mmol/L, group A), normal serum Mg concentration (0.77 mmol/L ≤ Mg2+ ≤1.03 mmol/L, group B), and hypermagnesemia (Mg2+ > 1.03 mmo/L, group C). The observed mean 24 h-peritoneal Mg clearance was 39.75 ± 17.42 mg. The mean normalized peritoneal Mg clearance rate was 1.82 ± 0.82 L/day/1.73 m2. A significantly lower 24-hour peritoneal Mg clearance was observed in group A vs group C. PD could partly clear serum Mg. They found a positive association of peritoneal Mg clearance with serum Mg concentration, which was concentration-dependent. Findings revealed a negative correlation of peritoneal Mg clearance with the residual renal function and a positive association with the nutritional status and daily peritoneal protein loss. Patients with high transport characteristics or continuous ambulatory PD (CAPD) had higher peritoneal Mg clearance.
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