Fang M, et al. - In this prospective, observational case series, investigators estimated 40 eyes of 29 candidates to study the retinal nonperfusion regions (NPR) in subjects with diabetic macular edema (DME) and also to evaluate its relationship with severity of DME. They observed a significant correlation between visual acuity and central macular thickness (CMT) and macular volume (MV). A positive association of NPR with leakage was noted with CMT and MV, while the NPR without leakage was negatively associated with CMT and MV. Significantly greater NPR with leakage in the posterior region was reported as compared to the mid-periphery and the far-periphery. They also recorded significantly greater NPR without leakage in the mid-periphery vs far-periphery or the posterior region.