Santer L, et al. - In 234 patients with heart failure (HF; 50% male) followed for 4.73 years, researchers determined the impact of chronic kidney disease (CKD), as defined by an estimated glomerular filtration rate (eGFR) value < 60mL/(min·1.73m²), on the associations of plasma LIPCAR with left ventricular remodeling and outcomes. They found that, compared with 17 age- and sex-matched controls, patients had increased LIPCAR. Also, LIPCAR showed a direct correlation with age (P=0.001) and with the maximal early transmitral flow velocity to the mean peak early diastolic velocity of the mitral annulus displacement ratio, and an inverse correlation with eGFR. Dependent of eGFR, associations of LIPCAR with hospitalization for HF, cardiovascular death, and a composite of hospitalization for HF or cardiovascular death were observed. CKD patients vs non-CKD patients had increased LIPCAR. Only non-CKD patients exhibited an independent association of LIPCAR with hospitalization for HF. Overall, plasma LIPCAR was identified as a prognosticator of outcomes in elderly HF patients without CKD. CKD modified the association of circulating LIPCAR with outcomes in HF patients.