Perez-Cornago A, et al. - A meta-analysis was conducted to investigate the connection between prediagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and prostate cancer risk. They assessed data from seven prospective trials from Japan and Europe. Findings revealed that circulating concentrations of genistein, daidzein and equol were not related to risk in men from Europe. No association was found between circulating lignan concentrations and the prostate cancer risk, overall or by disease aggressiveness or time to diagnosis. The evidence did not strongly suggest that prediagnostic circulating concentrations of isoflavones or lignans were related to prostate cancer risk.