Circulating endothelial cells as predictor of long‐term mortality and adverse cardiovascular outcomes in hemodialysis patients
Seminars in Dialysis Dec 10, 2020
Mohandas R, Diao Y, Chamarthi G, et al. - Researchers investigated whether the numbers of circulating endothelial cells (CEC) may afford a new tool for predicting long‐term survival as well as cardiovascular events in hemodialysis patients. This study involved 54 hemodialysis patients, who underwent enumeration of their CEC number. High CEC was identified to be related to worse cardiovascular survival and adverse cardiac events. Multivariate analysis revealed a 4‐fold elevated risk of adverse cardiac events in correlation with CEC > 20 cells/ml, while there was no statistical difference in all‐cause death and cardiovascular death. Findings revealed that long term future adverse cardiovascular events in hemodialysis patients were strongly predicted by a single measurement of CEC. CEC was suggested to possibly be a novel biomarker for evaluating cardiovascular risk in dialysis patients.
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