Yamamura S, et al. - Investigators estimated 58 type 1 diabetes cases of mean age 54.1 years, positive for glutamic decarboxylase-65 autoantibodies (GADA)-radioimmunoassay (RIA) to study the correlation between titers of islet autoantibodies ie, the C-X-C motif chemokine 10 (CXCL10) (a circulating chemokine activating the T-helper 1 cells leading to β-cell destruction) and β-cell function. They observed a significant decrease in C-peptide index (CPI) in with the progression of disease duration. They found that GADA titers by RIA and enzyme-linked immunosorbent assay (ELISA) were strongly associated with CPI in individuals with acute-onset type 1 diabetes with shorter disease duration (≤ 10 years) (not in those with longer duration or slowly progressive type 1 diabetes). They also reported no association of CPI with either insulinoma-associated antigen-2 autoantibodies (IA-2A) or zinc transporter 8 autoantibodies (ZnT-8A) titers.