White PC, et al. - Authors tested the presumption that there was a probable influence of cigarette smoke extract (CSE) and its components/metabolites nicotine, cotinine and thiocyanate (SCN-) on the neutrophil functions. As per data, ex vivo neutrophil activation could be altered with CSE by mechanisms independent of SCN- and nicotine. They noted a probable contribution of SCN- in the perturbed innate immune responses observed in smokers. Reduced speed, velocity, and directionality relative to untreated neutrophils were exhibited by neutrophils pre-treated with CSE.