Schwarzenberg SJ, et al. - In this investigation, researchers studied the natural history of chronic pancreatitis (CP). Patients were compared in the North American Pancreatitis Study2 (NAPS2; adults) and International Study Group of Pediatric Pancreatitis: Seeking a Cure (INSPPIRE; pediatric). Using appropriate statistical tests for categorical and continuous variables, demographics, risk factors, disease duration, management and outcomes of 224 children and 1,063 adults were assessed. Children were more likely to experience obstructive factors, according to findings. In children, genetic risk factors were more frequent. There was similar exocrine pancreatic insufficiency. In adults, diabetes was more prevalent than in children. Despite differences in onset age, there were similarities across demographics, CP treatment, and pain among children and adults with CP. Differences between groups in radiographic findings and the prevalence of diabetes might be associated with differences in disease-related risk factors and duration of CP. Alcohol was the only risk factor significantly more common in the cohort of NAPS2 subjects with childhood-onset (NAPS2-CO) vs the cohort of INSPPIRE participants.