Cruz-Almeida Y, et al. - Researchers examined adults aged 60-83 years to study the associations between chronic pain and a brain aging biomarker. From the Neuromodulatory Examination of Pain and Mobility Across the Lifespan study (N = 47), participants completed demographic, psychological, and pain assessments followed by a quantitative sensory testing battery and T1-weighted magnetic resonance imaging. Using an established machine-learning model, a brain-predicted age difference was estimated. People with chronic pain (n=33) had “older” brains for their age vs those without. The investigators noted an “older” brain in association with greater average worst pain intensity. Participants with chronic pain who reported treatments during the past 3 months had “younger” brains vs those who did not. They noted the significant association of an “older” brain with decreased vibratory and thermal detection, deficient endogenous pain inhibition, lower positive affect, and a less agreeable and less emotionally stable personality.