Garces S, et al. - Given that the presence of expanded proliferation centers (PCs) in lymph nodes involved by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has been associated with adverse clinical outcomes, researchers intended to determine the frequency and significance of PCs in bone marrow (BM) by analyzing data of 36 subjects with BM involvement by CLL in which PCs were present. Compared with the control group, patients with PCs in BM had significantly shorter overall survival. Findings revealed that PC's in BM were correlated with increased TP53 alterations, complex karyotype, and worse outcomes. Data reported that the identification of PCs in BM samples involved by CLL was correlated with adverse prognostic features.