Findings demonstrate an independent association between serum cholesterol-uptake capacity (CUC; a rapid cell-free assay system that directly assesses the capacity of HDL to accept additional cholesterol) level at index percutaneous coronary intervention (PCI) and subsequent revascularization post-PCI. Subsequent revascularization after PCI might be predicted by continuously evaluating high-density lipoprotein (HDL) functionality by CUC.

• In this retrospective review, 74 PCI patients who had subsequent revascularization and 183 patients who had follow-up coronary angiography without revascularization were included.

• The revascularization group had significantly lower serum CUC level at the index PCI, vs the non-revascularization group (84.3 [75.2–98.9] vs 92.0 [81.6–103.3 A U.]).

• In multivariate logistic regression analysis, reduced serum CUC level at the index PCI was shown to be independently linked with subsequent revascularization (odds ratio, 0.98).

• In the revascularization group, serum CUC level at the index PCI and follow-up and the absolute alteration in serum CUC level from the index PCI to follow-up were significantly lower, compared with those in the non-revascularization group, post-adjusting for 16 cardiovascular risk factors.