Ali T, et al. - Researchers investigated how childhood secondhand tobacco smoke (SHS) exposure influences ovarian reserve among nonsmoking women seeking fertility care. They also sought for a possible interaction with NAT2 genotype, given NAT2 enzyme is important in the metabolism and detoxification of xenobiotic substances found in tobacco smoke. A total of 101 nonsmoking women of reproductive age were inquired about demography and SHS exposure. Childhood SHS exposure inside the home was quantified as never, rarely, often or daily. They reported a higher odds of diminished ovarian reserve among participants who were ever exposed to childhood SHS inside the home vs no childhood SHS exposure. No effect modification by NAT2 was evident.