Aarestrup J, et al. - Researchers conducted a cohort study of 155,958 girls from the Copenhagen School Health Records Register, born 1930 to 1989 with measured weights and heights from 7 to 13 years, to assess if childhood body mass index (kg/m²), height, and growth patterns were associated with ovarian cancer overall and by histologic subtypes, including effects of birthweight. Girls with overweight had increased risks of ovarian cancer overall, mucinous, endometrioid, and clear cell ovarian cancers, but not serous and other ovarian cancers when compared with non-overweight girls at most ages. They noted positive and significant associations of childhood height with ovarian cancer overall and the endometrioid subtype but not with the other subtypes. Findings thereby suggest a link of ovarian carcinogenesis to childhood overweight, tallness, and growth, with variations across histological subtypes, indicating that early life plays a role in the origins of this disease.