Childhood bradycardia associates with atrioventricular conduction defects in older age: A longitudinal birth cohort study
Journal of the American Heart Association Sep 30, 2021
Topriceanu CC, Moon JC, Hardy R, et al. - Longitudinal birth cohort data show that childhood bradycardia triples the risk of developing atrioventricular conduction abnormalities in later life, with 88% of these anomalies being benign. Furthermore, it has no effect on mortality or heart size and function.
One in every three older persons with atrioventricular conduction defects had been bradycardic in childhood, with 12% having serious problems (Mobitz type II second‐degree atrioventricular block or higher).
Childhood bradycardia was related to 2.91 greater risks of atrioventricular conduction defects in fully adjusted models.
In random coefficients mixed generalized linear models, associations persisted.
A linear connection between the log chances of atrioventricular conduction abnormalities at 60 to 64 years of age and resting heart rate at 7 years of age was established using fractional polynomials.
There was no link found between childhood bradycardia and mortality outcomes, or between echocardiographic parameters and ventricular conduction abnormalities in older age.
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