Childhood body mass index is associated with risk of adult colon cancer in men: An association modulated by pubertal change in body mass index
Cancer Epidemiology, Biomarkers & Prevention Apr 08, 2019
Célind J, et al. - Among 37,663 men from the BMI Epidemiology Study, researchers assessed the independent links for childhood body mass index (BMI) and pubertal BMI change with risk of colorectal cancer. The participants were born in 1946 to 1961. At 8 (childhood) and 20 (young adult age) years of age, the weight and height of these subjects were measured. Using the Swedish National Patient Register (257 cases of colon cancer and 159 cases of rectal cancer), data were obtained on colorectal cancer. Increased risk of colon cancer was observed in relation to childhood BMI at 8 years of age, but not in association with pubertal BMI change. Findings revealed an association of childhood BMI with risk of colon cancer in individuals with a pubertal BMI change above, but not below, the median. They concluded high childhood BMI was related to increased risk of colon cancer only if it was followed by a pubertal BMI increase above the median.
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