Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome
Annals of Intensive Care Apr 02, 2019
Hamon A, et al. - Since a link has been reported between lung fibroproliferation in acute respiratory distress syndrome (ARDS) patients and mortality, and alveolar procollagen III (NT-PCP-III) represents a validated biomarker of lung fibroproliferation, researchers assessed ARDS patients with high levels of NT-PCP-III for lung fibroproliferative CT scan (computerized tomography scan) features. The participants in this retrospective study had ARDS and underwent at least one evaluation of alveolar NT-PCP-III and a chest CT scan 3 days prior to or following NT-PCP-III assessment. Fibroproliferation was represented by an alveolar level of NT-PCP-III > 9 µG/L. Based on the severity of the abnormalities, they scored each lobe from 0 to 5. Patients with active lung fibroproliferation had significantly higher CT scan fibrosis score when alveolar level of NT-PCP-III was used as a substitute indicator of histological lung fibroproliferation. Diagnosis of fibroproliferation during ARDS was mainly hindered by pulmonary condensation.
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