Allswede DM, Addington J, Bearden CE, et al. - Among help-seeking people at clinical high risk for psychosis, researchers undertook this inquiry to characterize differences in outcomes by exploring covariant longitudinal patterns of symptoms and functioning. In an initial discovery sample with 422 clinical high-risk people, the experts applied group-based multitrajectory modeling to longitudinal ratings of four symptom domains (positive, negative, disorganized, general) and general functioning. To test replicability, they used an independent sample (N = 133). In the discovery sample, they identified 3 trajectory groups. In an independent sample, these groups as well as remission patterns were replicated. Findings revealed that distinctive profiles of change over time in symptoms and functioning can enable the ascertainment of replicable subgroups of help-seeking clinical high-risk cases. The patterns of change (ie, rapid, moderate, or no improvement) noted across the four symptom domains and functioning were found to be similar within each of the three identified subgroups. The syndrome consistency of clinical high-risk symptoms and signs was supported by this new finding— the consistency of change over time across domains within each subgroup. Varying degrees of need for clinical interventions, ranging from minimal or supportive for approximately one-third of cases to increasingly intensive among the rest, was suggested by the detected trajectory subgroups.