Sinha N, et al. - The purpose of this trial was to characterize the genome-wide copy number aberrations (CNA) in colonic mixed adenoneuroendocrine carcinoma (MANEC) and neuroendocrine carcinoma. Similar and distinct, CNAs were illustrated in MANEC compared to adenocarcinoma. This, in turn, pointed towards the significant role for the MYC pathway of colonic carcinoma with neuroendocrine differentiation. The discovery of recurrent PTGER4 amplification implied a potential of exploring targeting therapy to the prostaglandin synthesis pathways in a subset of these tumors.