Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation
Fertility and Sterility Mar 31, 2019
Mamsen LS, et al. - Researchers performed a retrospective case–control study including 15 girls and young women with Turner syndrome (TS) aged 5–22 years at ovarian tissue cryopreservation (OTC) together with 42 control girls and young women aged 1–25 years who underwent OTC because of cancer, in order to describe ovarian follicles of girls and young women with TS who underwent OTC. They identified follicles in 60% of the biopsies (9 of 15) from TS ovaries. The follicle density was within the 95% confidence interval of the control group in 78% of the ovaries (7 of 9) with follicles. A high rate of abnormal follicle morphology was observed. As per findings, only a highly selected group of TS mosaic patients in whom a sizeable pool of normal follicles is present at OTC may benefit from OTC.
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