Jahandideh D, et al. - Using late night salivary cortisol (LNSC), researchers characterized a cohort of patients with cyclic Cushing's disease (CD) in comparison with noncyclic CD. In addition, they studied the diagnostic sensitivity of LNSC in comparison with that of 24-hour urine-free cortisol (UFC) in this population. It was a retrospective study of patients with CD between 2008 and 2017. Findings suggested that patients with cyclic CD account only for a minority of those with CD, but might require a lengthier diagnostic evaluation. As compared to UFC, the use of LNSC on multiple occasions provided a more sensitive method of detecting cyclic CD. Data reported that outcomes of transsphenoidal pituitary surgery (TSS) in cyclic CD were comparable to those with a noncyclic disease. No differences in remission and recurrence rates between subjects with cyclic CD and those with noncyclic CD was found.