Tao B, Xiao Y, Cao H, et al. - In chronic schizophrenia, there has been documentation of the corpus callosum (CC) deficits. In order to determine the long-term impacts of antipsychotic monotherapies on callosal anatomy, researchers herein compared the micro- and macro-structural characteristics of the CC in never-treated patients and those with long-term mono-antipsychotic treatment.

• Researchers obtained high resolution structural images and diffusion tensor imaging (DTI) data of 23 clozapine-treated schizophrenia patients (CT-SCZ), 19 risperidone-treated schizophrenia patients (RT-SCZ), 23 never-treated schizophrenia patients (NT-SCZ), and 35 healthy controls (HCs).

• NT-SCZ had significant deficits in the total and sub-regional CC volume and white matter integrity when compared with healthy individuals.

• Significantly increased fractional anisotropy (FA) values in the anterior CC region were recorded for both CT-SCZ and RT-SCZ when compared with NT-SCZ, while significantly increased volume in the mid-anterior CC region was evident only in RT-SCZ.

• CT-SCZ vs HCs showed significantly smaller volume of the mid-anterior CC region.

• Clinical symptoms in schizophrenia patients did not correlate with their callosal metrics.