Levy JK, Darmstadt GL, Ashby C, et al. - Investigators explored the landscape of gender-transformative programmes that attempt to influence health-related outcomes; to distinguish mechanisms through which successful programmes work, and to highlight where gaps might exist in implementation and evaluation. They systematically examined rigorous evaluations published between January 1, 2000, and November 1, 2018, of programmes that tried to reduce gender inequalities and transform restrictive gender norms to promote the health and wellbeing of 0–24-year-olds. They enrolled rigorously evaluated health programmes that matched the Interagency Gender Working Group definition of gender-transformative programming, regardless of where in the world they were implemented and what area of health they focused on. They searched 22,993 articles to identify 61 evaluations of 59 programmes. This study can expedite efforts to enhance global health by leading to more strategic investment in programmes that improve gender equality and target restrictive gender norms among young people. They demonstrated that such applications can lead to a lifetime of increased health and wellbeing by examining not only attitudes and behaviours related to gender at an early age, but also the gendered systems that surround them.