Veltkamp R, Pearce LA, Korompoki E, et al. - In this secondary analysis of a randomized clinical trial, researchers assessed the features and etiology of recurrent strokes following embolic strokes of undetermined source (ESUS). This trial (NAVIGATE-ESUS) was conducted between December 23, 2014 and October 5, 2017. In total, 309 patients (205 men [66%]; mean [SD] age, 68 [10] years) had ischemic stroke recognized during the median follow-up of 11 (interquartile range [IQR], 12) months (annualized rate, 4.6%). According to findings, the majority of recurrent strokes following ESUS were embolic and of undetermined source. Atrial fibrillation-related recurrences were in the minority, but were more commonly disabling and fatal. More thorough research to identify the embolic source is necessary for an effective antithrombotic strategy. There was no significant difference in risk of recurrence by subtype between treatment groups. Location of infarct was more often in the left vs the right hemisphere or brainstem or cerebellum for both the qualifying and recurrent strokes.