Mir TA, et al. - In this cross-sectional study, researchers analyzed the incidence, common injury mechanisms, and economic burden of open globe injuries in the United States. From January 1, 2006, to December 31, 2014, all ED visits of individuals with a primary diagnosis of open globe injury in the Nationwide Emergency Department Sample (NEDS) were evaluated. In total, 124, 989 ED visits for open globe injuries were evaluated, with an incidence of 4.49 per 100,000 population in the United States from 2006 to 2014 (mean [SD] age of study candidates, 37.7 [22.5] years; 94,078 [75.3%] male). Being struck by or against an object or person was the most common injury mechanism. The incidence of open globe injuries declined from 2006 to 2014 in the United States. While the data are from 5 to 13 years ago, these results tend to provide valuable information for targeting preventive measures against high-risk individuals; targeting young men with lower socioeconomic status and individuals 70 years or older at an increased risk of falls may help to reduce the incidence of open globe injuries.