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Characteristics and prevalence of domestic and occupational inhalational exposures across interstitial lung diseases

Chest Feb 26, 2021

Lee CT, Adegunsoye A, Chung JH, et al. - Whether domestic as well as occupational inhalational exposures would be common and related to disparities in demographics, clinical features, and transplant-free survival in patients with all types of interstitial lung disease (ILD), was investigated in this study with 156 patients. The presence of potentially relevant inhalational exposures was evident in 101 (65%) patients. A history of any exposure, occupational exposure and multiple exposures was present more in males than females. An association of white race with bird and hobby exposure was identified. Overall, the presence of potentially relevant inhalational exposures in a majority of patients, across all forms of ILD, was found via a standardized interview. Exposures varied markedly on the basis of demographics and were identified to be related to worse transplant-free survival, however, this survival difference was not significant following multivariable adjustment. Actionable targets in ILD management include detection as well as avoidance of exposures.

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