Shekerdemian LS, Mahmood NR, Wolfe KK, et al. - In this cross-sectional study, researchers provided an early description and characterization of coronavirus disease 2019 (COVID-19) infection in North American pediatric intensive care units (PICUs), concentrating on the mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes. They involved children positive for COVID-19 admitted to 46 North American PICUs between March 14 and April 3, 2020, with follow-up to April 10, 2020. Of the 48 children with COVID-19 admitted to partaking PICUs, 25 (52%) were male, and the median (range) age was 13 (4.2-16.6) years. In total, 40 children (83%) had preexisting underlying medical conditions, 35 (73%) presented with respiratory symptoms, and 18 (38%) had invasive ventilation, and the hospital mortality rate was 4.2%. This early study reveals that COVID-19 can lead to a significant burden of disease in children but confirms that severe illness is less frequent and that early hospital outcomes are better in children than in adults. Prehospital comorbidities seem to be an important factor in children. Such preliminary observations offer an important platform for larger and more extensive studies of children with COVID-19 infection.