Goldstein SA, Green J, Huber K, et al. - Researchers investigated the clinical distinction between patients with atrial fibrillation (AF) and thyroid disease and those with AF and no thyroid disease. They also investigated the efficacy of anticoagulation for the prevention of AF-associated thromboembolic events in patients with thyroid disease. They classified enrollees of ARISTOTLE, which compared apixaban with warfarin in patients with AF (n = 18,201), based on thyroid disease history at randomization (hypothyroidism, hyperthyroidism, and no thyroid disease). The likelihood of being female was greater among patients with hypo- or hyperthyroidism vs those without a history of thyroid disease. Older age and a greater likelihood of having prior falls were observed in patients with hypothyroidism. Although baseline features varied between patients with and without thyroid disease, similarities were evident in their clinical outcomes. The noninferiority of apixaban to warfarin was also evident, irrespective of thyroid disease history.