Liu X, et al. – In this cohort of 121,335 US men and women without diabetes, cardiovascular disease, cancer, or obesity, researchers studied relationships between intake of different types of fat and long-term weight change over a 20- to 24-year follow-up period. Data from this study showed that a 5% increase in energy from polyunsaturated fatty acid (PUFA) was related to less weight gain, and that increased intake of monounsaturated fatty acid (MUFA) from animal sources by 1% was related to weight gain of 0.29 kg. However, there was no evident association of MUFA from plant sources with weight gain. The researchers concluded that different dietary fats have divergent relationships with long-term weight change in this patient population. Replacing saturated and trans-fats with unsaturated fats, particularly PUFAs, may contribute to the prevention of age-related weight gain.