Van Hulst K, et al. - In this longitudinal, observational cohort study, researchers measured changes in objective and subjective drooling severity measures following submandibular botulinum neurotoxin A injection in children with neurodevelopmental disabilities, investigated their connection, and evaluated whether clinically relevant responses relate to changes in the impact of drooling. Study participants included 160 children (92 males, 68 females; 3–17y, mean 9y 1mo, SD 3y 6mo) treated between 2000 and 2012 at the Radboud University Medical Center, Nijmegen, the Netherlands. Data reported that 112 children (70%) were responders. Compared with baseline, their mean Visual Analogue Scale for drooling severity and DQ5 scores were significantly lower 32 weeks postintervention. Notably, only a ‘fair’ correlation was found between objective and subjective outcome measures at 8 weeks posttreatment. Positive changes regarding the impact of drooling on daily care and social interactions have followed a clinically relevant response based on a combination of objective and subjective measures of drooling severity.