Hernandez-Santiago V, et al. – Via conducting a population-based interrupted time series study to improve antimicrobial use, researchers examined changes in broad-spectrum antimicrobial prescribing in the community and resistance in people hospitalized with community-associated coliform bacteremia associated with a primary care stewardship intervention. According to findings, there was reversal of a previously rising rate of fluoroquinolone resistance and flattening of previously rising rates of cephalosporin and co-amoxiclav resistance. The investigators acknowledged that there were some limitations to their study. They noted, for example, that associations are not definitive evidence of causation and that potential effects of underlying secular trends in the postintervention period and/or of other interventions occurring simultaneously cannot be definitively excluded. Compared with prior trends, there were significant decreases in community broad-spectrum antimicrobial use in relation to the stewardship intervention. Changes in resistance among coliform bacteremia, however, were not as significant. The authors concluded that prevention of resistance through careful use of new antimicrobial agents may be more efficacious than attempting to reverse established resistance.