Lam NN, Lloyd A, Lentine KL, et al. - To assess kidney function following living donor nephrectomy as well as to determine how it varies by donor features, researchers undertook this retrospective matched cohort study in Alberta, Canada between 2002-2016, including living kidney donors, and linked healthcare administrative databases were utilized. Overall 604 donors were matched to 2,414 healthy non-donors from the general population. The rate of estimated glomerular filtration rate (eGFR) alteration over time (median follow-up 7 years; maximum 15 years) was assessed as the primary outcome. Overall, from six weeks onwards, an increment in the eGFR by +0.35 mL/min/1.73 m² per year was evident in donors and eGFR was shown to reduce significantly by -0.85 mL/min/1.73 m² per year in the matched healthy non-donors. Post-donation kidney function was shown to rise, on average, initially by 1 mL/min/1.73 m² per year due to glomerular hyperfiltration which started to plateau by five years after donation, in contrast to the steady age-associated reduction in kidney function among non-donors. Therefore, a significant difference in the average alteration in eGFR over time was evident between donors and non-donors.