Hoover SE, Gower BA, Cedillo Y, et al. - Given a possible contribution of altered satiety hormones to obesity in women with polycystic ovarian syndrome (PCOS), and the possible influence of diets with a low glycemic load (GL) on appetite regulating hormones including glucagon and ghrelin, researchers here examined if the hypothesis that after a 4-week, eucaloric low vs high GL diet habituation, a low vs high GL meal will raise glucagon and reduce ghrelin to reflect greater satiety and enhance self-reported fullness. They performed secondary analysis of a randomized crossover trial including 30 women diagnosed with PCOS. Low (41:19:40% energy from CHO:protein:fat) and high (55:18:27) GL diets were provided to the participants for 8-weeks each. At each diet midpoint, they were administered a solid meal test to determine postprandial ghrelin, glucagon, glucose, insulin, and self-reported appetite scores. Outcomes indicate that following low GL diet habituation, a low GL meal decreases ghrelin and enhances glucagon in women with PCOS