Sprung CL, Ricou B, Hartog CS, et al. - Researchers examined changes in end-of-life practices in European intensive care units (ICUs) from 1999-2000 to 2015-2016. Ethicus-2, a prospective observational study performed at 22 European ICUs previously included in the Ethicus-1 study (1999-2000), included 1,785 patients who had limitations in life-prolonging therapies or died. comparison between the 1999-2000 cohort vs 2015-2016 cohort was performed. Compared with data from patients included in the 1999-2000 cohort (n = 2,807), data from the patients in 2015-2016 cohort indicated treatment limitations (withholding or withdrawing life-sustaining treatment or active shortening of the dying process) significantly more frequently (89.7% vs 68.3%), whereas death without any limitations in life-prolonging therapies significantly less frequently (10.3% vs 31.7%). Findings thereby suggest that in European ICUs, end-of-life care practices have changed from 1999-2000 to 2015-2016, with more limitations in life-prolonging therapies and fewer deaths without treatment limitations.