Buckland G, et al. - In this study, researchers evaluated whether lifestyle intervention in survivors of breast cancer could influence dietary biomarkers of fruits, vegetables, and fatty acids. For this investigation, 37 overweight/obese patients with early-stage breast cancer completed a 12-week diet and exercise intervention. The intervention involved 1-hour weekly dietary sessions conducted by a dietician and 75-minute biweekly physical activity sessions of moderate-to-high intensity conducted by trained monitors. During the intervention period, Wilcoxon signed rank tests were used to evaluate changes in dietary and biomarker measurements. There was a significant increase in the intake of dietary carotenoids but not plasma carotenoids levels after the intervention. The investigators discovered a significant decrease in the percentage of saturated fatty acids and n-6 polyunsaturated fatty acids and an increase in monounsaturated fatty acids and total and long-chain n-3 polyunsaturated fatty acids with regard to erythrocyte membrane fatty acid levels. After a short-term diet and exercise intervention in this study population, significant changes in dietary nutrients and fatty acid biomarkers were noted, implying positive dietary changes that might be relevant to the prognosis of breast cancer.